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Drugs Ingredients Section / 11 Jun 2019

ALENDRONATE

Generic Name : ALENDRONATE

ABSTRACT -

Alendronate is a drug that is used to treat osteoporosis, gonadal failure and other conditions like steroid use. It is generally used when there is a potential risk of bone fracture due to osteoporosis. A bisphosphonate used to treat Paget’s bone disease, Alendronate inhibits bone resorption by working on osteoclasts to increase bone mineral density.

DOSAGE –

  • Alendronate is to be taken as directed by the doctor.
  • The general dosage is to be consumed once a day, or once a week. Consult your doctor regarding the intensity and frequency of drug consumption.
  • Alendronate is to be ingested half an hour before consuming any food or water in the morning.
  • The tablet is generally consumed whole along with a plain glass of water.
  • General adult dosages available –
  • Tablet - 35mg, 40mg, 70mg Effervescent tablet – 70mg/75mL

SIDE EFFECTS –

Diagnosis is usually recommended to –

  • Decrease in serum calcium
  • Decrease in serum phosphate
  • Myalgia
  • Arthralgia
  • Ostalgia
  • Abdominal pains
  • Heartburns
  • Severe joint pains or muscle pains

RARE SIDE EFFECTS:

  • Constipation
  • Upset stomachs
  • Pain in the facial area
  • Skin rashes
  • Diarrhea
  • Stomach bloating (gas)
  • Headaches
  • Severe Nausea

DRUG INTERACTIONS –

  • Deferasirox
  • Etelcalcetide
  • Alendronate has major interactions with two drugs.


    MODERATE DRUG INTERACTIONS –
  • Amikacin
  • Aspirin
  • Bevacizumab
  • Bromfenac
  • Bumetanide
  • Calcium acetate
  • Celecoxib
  • Diclofenac
  • Denosumab
  • Etodolac
  • Fenoprofen
  • Foscarnet
  • Gentamicin
  • Ibuprofen
  • Kaolin
  • Magnesium lactate
  • Streptomycin

Alendronate has moderate interactions with 220 different drugs

PRECAUTIONS –

  • Provide your doctor with a detailed and accurate medical history before drug prescription. Notify your doctor if you have indigestion, hypocalcaemia, kidney diseases, dental problems or problems that cause malabsorption.
  • Brush and floss teeth regularly during course
  • Do not consume Alendronate in case of an allergy or if you have low levels of calcium in your blood, or have problems with your esophageal tract.
  • While using the effervescent tablet, notify your doctor of your diet – as this tablet contains a sizeable amount of sodium.
  • Avoid Alendronate altogether if you find it difficult to stand up or sit upright 30 minutes after ingesting the medication.
  • Do not smoke or consume large amounts of alcohol during course.
  • Notify your doctor in case you use drugs like NSAIDs (Non-steroidal anti-inflammatory drugs) or aspirin.

WARNINGS –

  • Notify a medical authority if symptoms like chest pains, heartburns, muscle spasms or unusual pains occur. These are signs or either esophageal problems or of new conditions centering the bones.
  • Certain factors, combined with this drug can cause a condition called ‘osteonecrosis’ which involves severe pains in the jaw and dental area. Chemotherapy is a catalyst to osteonecrosis.
  • Keep out of reach of children.
  • In case of overdose, try not to vomit or lie down. Get medical help or contact a Poison Control Center immediately.

Have any questions? or Need help Contact us – 022 6163 6163 | support@medicus.com

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