GRANIX

09 Sep 2019

Generic Name : Generic Name : TBO-FILGRASTIM

 

ABSTRACT –

Granix is classified as a colony stimulating factor. This drug is an artificially created protein that is used to reduce the duration of extreme neutropenia. Neutropenia, a disorder where white blood cells are in lacking due to specific kinds of cancer medications -–is reduced in duration because of consumption of Granix, which stimulates the growth of these very white blood cells, that fight against infection.

DOSAGE –

  • Granix is to be taken as directed by the doctors. Consume this drug only as prescribed to avoid overdose or other harmful effects.
  • This drug is to be administered subcutaneously. Self administering may be taught to the patient.
  • The initial dose of this drug is given a day after chemotherapy dosage, and to be administered regularly till blood cell counts return to a healthy number.
  • Disposable syringes are for singular use only.
  • General Adult Dosage available:
    Injection – 300mcg/0.5m:, 480mcg/0.8mL

SIDE EFFECTS –

  • Bone pain

RARE SIDE EFFECTS:

  • Capillary leak syndrome
  • Stomach pain
  • Back pain
  • Bloody urine
  • Kidney problems
  • Fever/infection
  • Acute Respiratory Distress Syndrome
  • Ruptured spleen

DRUG INTERACTIONS –

  • Aldesleukin
  • Azacitidine
  • Belinostat
  • Bendamustine
  • Busulfan
  • Bosutinib
  • Carmustine
  • Cytarabine
  • Clofarabine
  • Dasatinib
  • Doxorubicin
  • Fuorouracil
  • Gemcitabine
  • Gemtuzumab

Granix has moderate interactions with 132 different drugs.

PRECAUTIONS –

  • Provide the doctor with a detailed and accurate medical history prior to drug prescription. Notify especially in case of illnesses and conditions such as sickle cell anemia, thalassemia, kidney diseases or upcoming radiation treatment/medical tests.
  • Do not use this drug in case of an allergy to Granix itself.
  • It may not be safe to nurse while on drug course. Consult a doctor regarding the same.
  • Inform the doctor of all the drugs being consumed so as to avoid severe drug interactions.
  • Avoid injecting into irritated skin.
  • Prepare injection only just before administering.
  • Do not administer this drug a day before chemotherapy dose.
  • Wash skin with soap and water in case of direct contact with medication.
  • Acetaminophen/Ibuprofen is recommended for the bone pain that may occur as a side effect because of this drug.

WARNINGS –

  • Keep out of reach of children. This drug is approved for children above the age of 1 month.
  • This drug can cause several risks such as spleen rupture or even capillary leak syndrome. Consult a doctor regarding the risks of consuming this drug – contact an emergency helpline as soon as possible in case of severe pain or emergency.
  • In case of overdose, get medical help or contact a Poison Control Center immediately.

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