ATROPINE

08 Aug 2019

Generic Name : ATROPINE (INJECTION/OPHTHALMIC)

ABSTRACT –

Atropine is a multi-purpose medication drug classified as an anticholinergic antispasmodic chronotropic antidote. This drug is often used during surgery or post-surgery to reduce secretions such as mucus or saliva within the airway. It is used as an antidote to treat specific types of poisoning and to treat spasms in the stomach, the bladder or the intestinal organs. The ophthalmic form of this drug is used to dilate the pupils in case of inflammatory infections, to treat amblyopia to strengthen a weal eye. This drug works by relaxing muscles in the eye and targeted parts of the body while reducing spastic movement or fluid secretion within the airway.

DOSAGE –

    • Atropine is to be taken as directed by the doctors.
    • The injection form of the drug is generally given into a muscle, under the skin or as an infusion through a vein.
    • Eye drops must be used as per doctor’s advice. Wait for 5 minutes between each drop.
    • General Adult Dosage available:

Injection – 0.1mg/mL, 0.4mg/mL
Ophthalmic – 1%, 2%

SIDE EFFECTS –

  • Dryness in the mouth, nose or throat
  • Blurry vision
  • Dizziness
  • Headaches
  • Mild eye pain/watery eyes (ophthalmic)

RARE SIDE EFFECTS:

  • A feeling akin to fainting
  • Pounding in the chest
  • Confusion
  • Restlessness
  • Difficulty swallowing
  • Hallucinations
  • Severe skin rash
  • Loss of balance
  • Severe redness/infection (ophthalmic)
  • Increase in blood pressure (ophthalmic)

DRUG INTERACTIONS –

  • Potassium chloride
  • Potassium citrate
  • Topiramate
  • Zonisamide

Atropine has major interactions with 4 different drugs.

MODERATE DRUG INTERACTIONS –

  • Acebutolol
  • Acrivastine
  • Amoxapine
  • Carteolol
  • Cisapride
  • Clomipramine
  • Doxepin
  • Ethanol
  • Fentanyl
  • Ketoconazole
  • Loxapine
  • Labetalol
  • Magaldrate
  • Morphine
  • Nadolol
  • Opium
  • Oxycodone
  • Pimozide
  • Quinapril
  • Sotalol
  • Timolol

Atropine has moderate interactions with 176 different drugs.

PRECAUTIONS –

  • Provide the doctor with a detailed and accurate medical history prior to drug prescription. Notify especially in case of illnesses such as asthmatic conditions, glaucoma, enlarged prostate, arrhythmia, liver / kidney disease, myasthenia gravis, blockage within the intestinal tract or hypertension.
  • Do not consume this drug in case of an allergy to Atropine itself.
  • Certain forms of Atropine may conserve preservatives that can be harmful to a newborn. Do not nurse while using the ophthalmic form of this drug as it may pass through breast milk.
  • Sensitivity to sunlight can increase while using the eye drops. Use sunglasses to protect your eyes.
  • Avoid dehydration while on drug course by drinking adequate amounts of water.
  • Avoid wearing contact lenses while using the eye drops.

WARNINGS –

  • Keep out of reach of children. This ophthalmic form of this drug is not approved for infants less than 3 months.
  • This drug can cause blurry vision. Avoid strenuous or complicated activities that may cause injuries while using this drug. The ophthalmic form of thus drug generally causes blurry vision for up to 2 weeks.
  • In case of overdose or swallowing of medication, get medical help or contact a Poison Control Center immediately.

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