BETAMETHASONE

14 Jun 2019

ABSTRACT –

Betamethasone belongs to the Glucocorticoid class of drugs. It is used in treating numerous diseases such as rheumatoid arthritis, systemic lupus erythematosus, dermatitis, psoriasis, various allergic conditions too which include asthma and angioedema. It is used to treat preterm labor babies, patients with Crohn’s disease. leukemia and adrenocortical insufficiency. It is given in the form of an injection or applied as lotion and cream.

DOSAGE –

  • Betamethasone has to be taken as directed by the doctors.
  • Prescribed dosage:
  • Injection: 6 mg/ml Cream: 0.5mg/1g Lotion: 0.5mg/1ml Ointment: 0.5mg/1g

SIDE EFFECTS –

  • Menstrual irregularity
  • Skin irritation
  • Depression
  • Euphoria
  • Adrenal suppression
  • Hypertension
  • Excessive hair growth
  • Petechiae i.e. small red patches on skin in bunch
  • Irritability
  • Rash

RARE SIDE EFFECTS:

  • Weakening of muscles
  • Psychosis
  • Fluid retention
  • Pulmonary edema
  • Papilledema

SHORT-TERM EFFECTS:

  • The patient can witness dryness in the skin and blurred vision.
  • Electrolytes and fluid disbalance have been observed.

LONG-TERM EFFECTS:

  • The long term treatment leads to Adrenal insufficiency.
  • The patient can develop Cushing’s syndrome.

DRUG INTERACTIONS –

  • Dofetilide
  • Efalizumab
  • Halofantrine
  • Haloperidol
  • Iohexol
  • Iopamidol
  • Levomethadyl
  • Macimorelin
  • Metyrapone
  • Mifepristone

MILD INTERACTIONS OF BETAMETHASONE ARE:

  • Abatacept
  • Acetaminophen
  • Acetohexamide
  • Altretamine
  • Bepridil
  • Chlorambucil
  • Darunavir
  • Enalapril
  • Gentamicin
  • Ketoconazole

PRECAUTIONS –

  • Take an allergy test if allergic to sulfites.
  • Keep a check on the weight as an overweight result in heart failure and hypertension.
  • Maintain the sterilized environment as a patient is at risk of getting various infections.
  • Take immune boosters regularly after consultation.
  • Move the body regularly to strengthen the muscles.

PREGNANCY AND LACTATION WITH BETAMETHASONE:

  • Avoid administration of the drug during pregnancy as it results in cleft palate, stillbirth, premature abortion and certain heart risk in the fetus.
  • The lactation suppresses the growth interferes the production of endogenous corticosteroids, weak muscles and certain skin problems in infants.

WARNINGS –

  • Do not stop the drug abruptly.
  • Consult the doctor for modified medication in case of increased blood sugar levels
  • Keep strengthening the bones as osteoporosis can happen.
  • Go for a checkup if there is prolonged constipation with irregular bowel movements.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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