BICALUTAMIDE

14 Jun 2019

Generic Name : BICALUTAMIDE

ABSTRACT –

Bicalutamide belongs to the anti-androgens class of drugs used primarily in the treatment of prostate cancer. It is used in combination with gonadotropin-releasing hormone (GnRH) or the removal of testicles surgically. It is also beneficially used for excessive hair growth treatment in in transgender as a procedure of feminine hormone therapy. It should never be consumed by a woman or child.

DOSAGE –

  • Bicalutamide has to be taken as directed by the doctors.
  • Prescribed dosage:
  • Tablet: 50 mg

SIDE EFFECTS –

  • Nausea
  • Dry skin
  • Abdominal pain
  • Breast tenderness
  • Gynecomastia (breast development) in males
  • Reduced penile length
  • Demasculinization
  • Erectile dysfunction
  • Decreased libido
  • Elevated liver enzymes

RARE SIDE EFFECTS:

  • Interstitial lung disease
  • Liver toxicity
  • Pulmonary fibrosis
  • Lung dysfunction

SHORT-TERM EFFECTS:

  • The patient can witness photosensitivity.
  • The patient suffers from sexual dysfunction.

LONG-TERM EFFECTS:

  • Treatment for long term leads to severe liver toxicity along with interstitial pneumonitis.
  • The angioedema may also occur.

DRUG INTERACTIONS –

  • Amoxicillin
  • Bosentan
  • Carbamazepine
  • Clathiromycin
  • Eliglustat
  • Dexamethasone
  • Delavirdine
  • Erythromycin
  • Fluoxetine
  • Fosphenytoin
  • Imantinib

MILD INTERACTIONS OF BICALUTAMIDE ARE:

  • Acetaminophen
  • Amiodarone
  • Aspirin
  • Chlorpheniramine
  • Fluconazole
  • Mifepristone
  • Nefazodone
  • Oxycodone
  • Sufentanil

PRECAUTIONS –

  • Take an allergy test for androgens.
  • Do not use the drug before sexual maturation.
  • Male patients should not consume the drug if planning for a baby.
  • Avoid overuse and consumption of drug for liver balance.
  • Get hepatic enzyme levels checked regularly.

PREGNANCY AND LACTATION WITH BICALUTAMIDE:

  • The drug usage during pregnancy leads to deformed fetus development and even death of the fetus.
  • Miscarriages are common during early pregnancy.
  • Breastfeeding affects the reproductive system along with the liver malfunctioning.

WARNINGS –

  • Do not stop the drug abruptly
  • In case of unbalanced hepatic enzymes, get modified medication.
  • In case of difficulty in breathing, consult a doctor immediately.
  • Avoid too much sugar according to the fluctuating glucose levels.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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