ABSTRACT – Hemophilia affects blood clotting proteins due to which blood doesn’t clot properly. Lower amount of clotting factor...
Hemophilia
Hemophilia affects blood clotting proteins due to which blood doesn’t clot properly. Lower amount of clotting factor VIII or IX is responsible for this disease. These patients bleed for longer after an injury than normal. Internal bleeding also might start which becomes life threatening if it happens in vital organ such as brain. Knees, ankles and elbows are more prone to bleeding. Hemophilia mostly affects males and females can be the carrier of this disease.
CAUSES –
Inherited disorder
Insufficient blood clotting
Formation of antibody to clotting factors(Autoimmune condition)
Spontaneous mutation of genes
SIGNS AND SYMPTOMS –
Excessive bleeding after any cut or an injury
Easy bruising
Prolonged and continuous bleeding even after getting ceased
Internal bleeding
Blood in urine or stool
Nose bleeding
Bleeding, swelling and pain in joints like knees, elbows
TREATMENT –
Replacement of clotting factors through injection or intravenously
Desmopressin (DDAVP) hormone
Medications such as anti-fibrinolytics
Vaccinations
Fibrin sealants to apply on wounds
Surgery
RISK FACTORS –
Family history of Hemophilia
EPIDEMIOLOGY –
1 to 3 individuals per million of the population gets affected from this disease worldwide.
Incidence of Hemophilia A is 1 in 5000 males and Hemophilia B is 1 in 30,000 males.
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