19 Sep 2019




Hydrochlorothiazide falls under the class of drugs called water pills or diuretics and used for controlling high blood pressure in the body. By lowering the level of blood pressure, it prevents the risk of heart strokes and kidney related problems. It works in the body by increasing the need for urination which helps to remove extra salt and water in the body. Further, the drug also helps in the reduction of edema which causes kidney and liver disorders as well as strokes.


  • Hydrochlorothiazide has to be taken as directed by the doctors.
  • Adult and pediatric dosages:
    Injection solution: 50 mg/5 mL
    Tablet: 12.5 mg; 25 mg; 50 mg; 100 mg


  • Abdominal pain
  • Weakness
  • Weight gain
  • Dry skin
  • Increased urination
  • Indigestion
  • Itching
  • Loss of appetite
  • Nausea or vomiting
  • Bloating
  • Blood in the urine or stools
  • Tightness in the chest
  • Pale skin
  • Trouble in breathing
  • Wheezing


  • Red spots on the skin
  • Light-headedness
  • Hair loss
  • Increased skin sensitivity to sunlight
  • Restlessness
  • Difficulty in bowel movement
  • Cramping
  • Loss in sexual ability
  • Muscle spasm
  • Severe sunburn
  • Weakness


  • Arsenic Trioxide
  • Cisapride
  • Dofetilide
  • Lithium
  • Pimozide
  • Tizanidine
  • Dolasetron
  • Dronedarone
  • Droperidol
  • Levomethadyl Acetate
  • Ziprasidone

Hydrochlorothiazide has major interactions with 13 different drugs.


  • Cyclosporine
  • Dapagliflozin
  • Avanafil
  • Baclofen
  • Furosemide
  • Ginkgo
  • Ketoprofen
  • Ketorolac
  • Oxycodone
  • Vortioxetine
  • Zaleplon
  • Zolpidem
  • Quinapril
  • Rabeprazole
  • Paliperidone
  • Nabilone

Hydrochlorothiazide has moderate interactions with 358 different drugs.


  • This drug contains inactive ingredients which may result in allergic reactions. So a pharmacist must be consulted before consuming it.
  • It is necessary to discuss any medical history related liver disease, kidney disease, skin cancer, lupus, diabetes or gout.
  • Since this drug makes a person dizzy so activities like driving and others which need more attention should be avoided.
  • Use of this drug might result in diarrhea or vomiting which leads to the risk of severe dehydration.
  • The medication has the potential to decrease potassium levels in the body. Therefore, salt substitutes which are potassium-rich should be used.
  • Increase the use of sunscreens as this medication makes the skin very sensitive to the sun.
  • Avoid consumption of alcoholic beverages.


  • Use of Hydrochlorothiazide in pregnancy may be acceptable only if the benefits exceed the risks involved.
  • Studies in animal pregnancy have shown adverse effects on fetus. But no adequate studies have been found in humans to access the damage involved.
  • Hydrochlorothiazide transfers into breast milk. Preferable precautions must be taken during breast feeding.


  • Diabetic patients should check their sugar levels regularly because the drug might have adverse effects on blood sugar levels.
  • Use of this medication is not considered safe and effective in children below 12 years of age.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

The Ultimate Pharma Guide

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