HYDROXYCHLOROQUINE

19 Oct 2019

 

Generic Name :HYDROXYCHLOROQUINE

 

ABSTRACT –

Hydroxychloroquine is used for treating infections caused by mosquitoes which lead to malaria. However, the drug is not effective in treating certain kind of malaria like chloroquine-resistant. In addition to this, the drug helps in treating other auto-immune diseases like arthritis, lupus or rheumatoid. The drug falls under the category of medications which are called as Disease-Modifying Antirheumatic Drugs (DMARDs). The use of this medication is helpful in preventing skin problems and also swelling in the case of arthritis.

DOSAGE–

  • Hydroxychloroquine has to be taken as directed by the doctors.
  • Adult and pediatric dosages:
    Oral Tablet: 400 mg orally on the same day every week

SIDE EFFECTS–

  • Blurred vision
  • Diarrhea
  • Difficulty in breathing
  • Dizziness
  • Irregular heartbeats
  • Headache
  • Joint or muscle pain
  • Loss of hearing
  • Stomach pain
  • Swelling in the feet or lower legs
  • Tiredness or weakness
  • Yellow eyes or skin

SIDE EFFECTS–

  • Irritation
  • Nausea
  • Nervousness
  • Nightmares
  • Shakiness and unsteady walk
  • Uncontrolled eye movements
  • Unsteadiness
  • Vomiting

DRUG INTERACTIONS–

  • Aurothioglucose
  • Bedaquiline
  • Droperidol
  • Efavirenz
  • Escitalopram
  • Fingolimod
  • Gatifloxacin
  • Nilotinib
  • Osimertinib
  • Panobinostat
  • Vigabatrin
  • Ziprasidone
  • Bepridil
  • Ivosidenib
  • Mesoridazine
  • Cabozantinib

Hydroxychloroquine has major interactions with 57 different drugs.

MODERATE DRUG INTERACTIONS –

  • Azithromycin
  • Duloxetine
  • Elotuzumab
  • Encorafenib
  • Granisetron
  • Rosuvastatin
  • Salmeterol
  • Nortriptyline
  • Ofloxacin
  • Voriconazole
  • Zafirlukast
  • Ketoconazole
  • Lactulose
  • Halothane
  • Histrelin
  • Benznidazole

Hydroxychloroquine has moderate interactions with 262 different drugs.

PRECAUTIONS–

  • This drug contains inactive ingredients which may result in allergic reactions. So a pharmacist must be consulted before consuming it.
  • It is necessary to discuss any medical history related to eye problems, blood disorders, diabetes, liver and kidney disease, and various skin problems.
  • Since this drug makes a person dizzy so activities like driving and others which need more attention should be avoided.
  • Use of this drug show more sensitive symptoms on adults like confusion, drowsiness or constipation.
  • This drug makes the skin very sensitive to the sun. So going out in the sun should be avoided
  • Avoid consumption of alcoholic beverages as it can have adverse effects on liver.

PREGNANCY AND LACTATION WITH HYDROXYCHLOROQUINE:

  • Use of Hydroxychloroquine in pregnancy may be acceptable only if the benefits exceed the risks involved.
  • Studies in animal pregnancy have shown adverse effects on fetus. But no adequate studies have been found in humans to access the damage involved.
  • Hydroxychloroquine transfers into breast milk. Preferable precautions must be taken during breast feeding.
  • The use of this drug is not effective for treating Rheumatoid Arthritis during pregnancy.

WARNINGS–

  • Use of this medication is not considered safe and effective for a long-term in children.
  • • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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