IBRANCE

21 Oct 2019

Generic Name :PALBOCICLIB

ABSTRACT-

The medication is used to treat certain kinds of breast cancer. It works as a chemotherapy drug to prevent the growth of cancer cells in the body. The drug is effectively used in both men and women for the treatment of HR-positive, HER2-negative breast cancer which also has the risk of spreading to other parts of the body. This medicine is given along with a hormonal medicine like letrozole in postmenopausal women.

DOSAGE–

  • Ibrance has to be taken as directed by the doctors.
  • Adult and pediatric dosages:
    Oral Tablet: 125 mg capsule once daily

SIDE EFFECTS–

  • Body ache
  • Chills
  • Cough
  • Ear congestion
  • Fever
  • Headache
  • Difficulty in urination
  • Sore throat
  • Trouble in breathing
  • Ulcers in the mouth
  • Bruising
  • Weakness

RARE SIDE EFFECTS:

  • Anxiety
  • Chest pain
  • Lightheadedness
  • Fainting
  • Hoarseness

DRUG INTERACTIONS–

  • Atazanavir
  • Conivaptan
  • Deferiprone
  • Delavirdine
  • Enzalutamide
  • Etanercept
  • Fingolimod
  • Itraconazole
  • Ketoconazole
  • Leflunomide
  • Saquinavir
  • Voriconazole
  • Yellow fever vaccine
  • Zoster vaccine live
  • Baricitinib

Ibrance has major interactions with 65 different drugs.

MODERATE INTERACTIONS OF IBRANCE ARE:

  • Azathioprine
  • Bexarotene
  • Cyclosporine
  • Dabrafenib
  • Fostamatinib
  • Ganciclovir
  • Ivosidenib
  • Oxcarbazepine
  • Panobinostat
  • Nafcillin
  • Quinidine
  • Typhoid vaccine, inactivated
  • Ustekinumab
  • Valganciclovir
  • Lanreotide
  • Danazol

Ibrance has moderate interactions with 215 different drugs.

PRECAUTIONS–

  • This drug contains inactive ingredients which may result in allergic reactions. So a pharmacist must be consulted before consuming it.
  • It is necessary to discuss any medical history related to liver and kidney diseases.
  • Avoid any type of immunizations or vaccinations while on drug course.

PREGNANCY AND LACTATION WITH IBRANCE:

  • Use of Ibrance during pregnancy is not recommended at all.
  • Both father and mother can have adverse effects on an unborn baby if on medicine course.
  • It is not known if Ibrance transfers into breast milk. But breast feeding should be avoided for at least 3 weeks after the last dosage of the drug.

WARNINGS–

  • The medication has a serious effect on the immune system of the body. It increases the risk of severe infections and unusual bleeding.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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