IBRUTINIB

22 Oct 2019

Generic Name :IBRUTINIB

ABSTRACT-

Ibrutinib is used to treat certain types of cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom macroglobulinemia. The drug falls under the class of drugs which are commonly known as kinase inhibitors. The drug works in the body by preventing the growth of cells that cause cancer in the body. Further, the medicine is also helpful in treating symptoms which occur due to stem cell transplant. It does so by weakening the immunity system of the body.

DOSAGE–

  • Ibrutinib has to be taken as directed by the doctors.
  • Adult and pediatric dosages:
    Oral Tablet: 70 mg; 140 mg; 280 mg; 420 mg; 560 mg

SIDE EFFECTS–

  • Belching
  • Decreased appetite
  • Bowel movement disorders
  • Heartburn
  • Indigestion
  • Lack of strength
  • Reddish skin patches
  • Muscle spasms
  • Small red spots on the skin
  • Stomach discomfort
  • Inflammation on the mouth

RARE SIDE EFFECTS:

  • Dark urine
  • Diarrhea
  • Difficulty in swallowing
  • Weakness
  • Skin rash
  • Joint pain
  • Swelling
  • Puffy eyes

DRUG INTERACTIONS–

  • Atazanavir
  • Baricitinib
  • Fosphenytoin
  • Golimumab
  • Heparin
  • Ibritumomab
  • Ketorolac
  • Leflunomide
  • Warfarin
  • Lepirudin
  • Measles virus vaccine
  • Crizotinib
  • Dabigatran
  • Nelfinavir
  • Oxaprozin
  • Typhoid vaccine, live
  • Urokinase
  • Varicella virus vaccine
  • Panobinostat

Ibrutinib has major interactions with 160 different drugs.

MODERATE INTERACTIONS OF IBRUTINIB ARE:

  • Azathioprine
  • Griseofulvin
  • Everolimus
  • Ivosidenib
  • Ketorolac ophthalmic
  • Niraparib
  • Ocrelizumab
  • Lanreotide
  • Felbamate
  • Ustekinumab
  • Valganciclovir
  • Cyclosporine
  • Danazol
  • Primidone
  • Quinidine
  • Bexarotene

Ibrutinib has moderate interactions with 167 different drugs.

PRECAUTIONS–

  • This drug contains inactive ingredients which may result in allergic reactions. So a pharmacist must be consulted before consuming it.
  • It is necessary to discuss any medical history related to kidney and liver problems, heart attacks, strokes, high blood pressure, bleeding problems, and high level of uric acid in the blood.
  • Since this drug makes a person dizzy so activities like driving and others which need more attention should be avoided.
  • The use of this drug may lead to worsening of current infections. Therefore cleanliness should be maintained.
  • Use of this drug show more sensitive symptoms on adults like irregular heartbeat rate, low level of red blood cells, and high blood pressure.
  • Avoid consumption of alcoholic beverages.

PREGNANCY AND LACTATION WITH IBRUTINIB:

  • Use of Ibrutinib in pregnancy may be acceptable only if the benefits exceed the risks involved.
  • Studies in animal pregnancy have shown adverse effects on fetus. But no adequate studies have been found in humans to access the damage involved.
  • It is not known if Ibrutinib transfers into breast milk. Preferable precautions must be taken during breast feeding.

WARNINGS–

  • It is important to not come in contact with people who are allergic to infections like chickenpox, measles, or flu.
  • It is not recommended to get any kind of vaccinations or immunizations while using this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

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